Xiaoli Fan, People's Republic of China
Zhongnan Hospital of Wuhan University
The organ preservation and enhancement of donation success ratio effect of extracorporeal membrane oxygenation in circulatory unstable brain death donor
Xiaoli Fan1, Zhiquan Chen1, David Nasralla2, Xianpeng Zeng1, Jing Yang1, Shaojun Ye1, Yi Zhang1, Guizhu Peng1, Yanfeng Wang1, Qifa Ye1.
1Transplant Center, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China; 2Transplant Center, Nuffield Department of Surgical Sciences, Oxford University, Oxford , United Kingdom
Institute of Hepatobiliary Diseases of Wuhan University.
Background and Aim: Between 2010 and 2013 our institution recorded 66 cases of failed organ donation after brain death due to the excessive use of the vasoactive drugs resulting in impaired hepatic and/or renal function. To investigate the effect of extracorporeal membrane oxygenation (ECMO) in donor management, from 2013 to 2015, ECMO was used to provide support for circulatory or respiratory failure DBD donors.
Methods: A retrospective cohort study between circulatory non stable DBD with vasoactive drugs (DBD-drug) and circulatory non stable DBD with ECMO (DBD-ECMO) was made to compare transplant outcome.
Results: 19 brain death donors have been supported by ECMO. The post-transplant liver PNF incidence was 10% (2/20) in DBD-drug group vs. 0 in DBD-ECMO group. Kidney function indicators including creatinine clearance and urine production were Significantly better in DBD-ECMO group, as well as decreased kidney DGF rate. Donation success rate increased steadily from 47.8% in 2011 to 84.6% in 2014 after ECMO intervention.
Conclusion: The use of ECMO in assisting circulatory and respiratory function of DBD can reduce liver and kidney injury from vasoactive drugs, thereby improving organ quality and reducing the organ discard rates.
The National Natural Science Foundation of Xinjiang joint fund key projects.
Lectures by Xiaoli Fan
| When | Session | Talk Title | Room |
|---|---|---|---|
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Sat-20 17:00 - 18:00 |
Deceased Donation - Campfire Table 3 | The development and management of China Organ Procurement Organization Alliance | Hall 5FG-Level 5 |
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Sat-20 17:00 - 18:30 |
Donation and Procurement Posters | The organ preservation and enhancement of donation success ratio effect of Extracorporeal Membrane Oxygenation in circulatory unstable brain death donor | Hall 5FG-Level 5 |
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Sat-20 17:00 - 18:30 |
Donation and Procurement Posters | Hypothermic machine perfusion attenuate liver warm ischemia injury on a novel venous bypass supported pig liver auto-transplantation model | Hall 5FG-Level 5 |