For the purpose of implementing the Regulations on Human Organ Transplantation and the Regulations on Procurement and Distribution of Organ Donation promulgated by National Health and Family Planning Commission of China (NHFPCC) in August 2013, promoting China Donation after Citizen’s Death (CDCD) and realizing healthy, ethical and scientific development of organ transplantation, the National Organ Donation and Transplantation Committee (NODTC) establishes China Organ Procurement Organization Alliance (COPO). COPO strictly abide by the Regulations on Human Organ Transplantation and regulations on organ donation and transplantation; devote itself to industrial management of Organ Procurement Organization (OPO) and scientific norms of CDCD and transplantation, and guarantee that citizen’s organ donation is the only source of organ transplantation. COPO is divided into seven regions based on the current situation and geographical factors of organ donation and transplantation in China. COPO responsibilities including: work out the trial measures for industrial norms and scientific management of organ procurement and living related organ procurement; work out a scientific rescue procedure of CDCD donor, a scientific quality assessment system of donated organs and formulate scientific norms of organ procurement; organize industrial experts to work out admittance criteria of OPO staff, OPO responsibilities, application qualifications of OPO medical institute, necessary facility standards of OPO operation and formulate OPO development and quality control standard; organize experts to account necessary costs of organ donation and procurement, and work out charging standard of principle and guidance fee; work out scientific norms and management measures of coordination and operation between OPO and transplant hospital, as well as service scope of OPO and operation code and norms of transplant hospital. A scientific OPO function and management mechanism has been found in China. Medical institute with organ transplantation qualification shall sign a contract with an OPO-qualified medical institute. OPO shall be responsible for organ procurement and ensure that the transplant hospital has priority in using the organ donated, and the transplant hospital shall pay related costs on organ donation and procurement to OPO. Besides, OPO shall sign an agreement with potential organ donation medical institutes and pay for the costs on donor’s rescue and maintenance to medical institutes of successful organ donation. Until 2016.01.29 in China, 65837 citizens have registered to be donation volunteers; 16707 organ failure patients have been cured by the organ retrieved from the 6171 successful donation cases. COPO is playing an important role in management of organ procurement in China and prompt the work of China organ donation after citizens’ death.